Lina Raffaella Barzaghi
We describes a unique case of life threatening radionecrosis in
a female affected by left parieto-temporal IDH-wildtype, WHO
grade II astrocytoma treated by partial resection, radiotherapy and
chemotherapy. Steroid, oral pentoxifylline, vitamin E, surgery and
bevacizumab (2 + 9 cycles) were given, obtaining a partial clinical
response, while signifiant radiologic reduction was documented. An
individual radiation hyper-sensivity was suggested in this patient
and data on this topic are higtly needed with increasing interest
in personalized medicine worldwide. Radionecrosis should be
considered after radiotherapy in low-grade astrocytoma, because
its course may be devastating and exacerbated by anti-tumoral
therapies.