Yanqiang Wang, Yuge Zhang, Yilong Shan2 and Zhengqi Lu
Neuromyelitis optica spectrum disorders (NMOSD), an autoimmune astrocytopathic disease associated with antiaquaporin- 4 (AQP4) antibody, is characterized by inflammatory lesions in the optic nerves, spinal cord, and central parts of the brain. These symptoms, urinary and fecal incontinence about conus medullaris involvement in NMOSD, are usually not appreciated as the possible manifestation of NMOSD. Missing diagnosis at this early stage will lead to a delay in the treatment, and hence, irreversible complications. We present two cases of conus medullaris involvements with neuromyelitis optica spectrum disorders.