Jean Bruno
A abecedarian principle in reproductive neuroendocrinology is coitus steroid feedback steroid hormones buried by the gonads circulate back to the brain to regulate the neural circuits governing the reproductive neuroendocrine axis. These nonsupervisory feedback circles eventually act to modulate Gonadotropin- Releasing Hormone (GnRH) stashing, thereby affecting gonadotropin stashing from the anterior pituitary. In ladies, rising estradiol (E2) during the middle of the menstrual( or estrous) cycle paradoxically “ switch ” from being inhibitory on GnRH stashing( “ negative feedback ”) to stimulating GnRH release( “ positive feedback ”), performing in a swell in GnRH stashing and a downstream LH swell that triggers ovulation. While upstream neural afferents of GnRH neurons, including kisspeptin neurons in the rostral hypothalamus, are proposed as critical loci of E2 feedback action, the underpinning mechanisms governing the shift between E2 negative and positive feedback are still inadequately understood.