Shanlin Tong
Tumour microenvironment plays an important role in
controlling tumour growth, metastasis and response to
therapy. These aspects are well studied in epithelial tumour
biology, but less described in mesenchymal lineage
derived soft tissue sarcomas (STS). One significantly under
researched STS type is rhabdomyosarcoma (RMS),
which is the most common STS in children. This study
focuses on how paediatric RMS regulate the behaviour
of its adjacent stromal cells as well as how the sarcoma
associated fibroblasts (SAF) affect the behaviour of cancer
cells. We aimed to investigate the crosstalk between
RMS and stromal cells to understand the mechanisms
of potential therapeutic relevance